abstract：:Antiplatelet therapy has been shown to significantly reduce the risk of serious vascular events in high-risk patients, including those with a prior acute ischemic event. The long-term use of antiplatelet agents is a key component of secondary prevention measures following acute coronary syndromes, including ST-segment...

journal_title：American heart journal

authors： Valgimigli M,Minarelli M

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:We perform a systematic review to discern if ST resolution achieved via percutaneous coronary intervention (PCI) has a different meaning to that achieved via fibrinolysis. BACKGROUND:Resolution of ST-segment elevation in acute myocardial infarction has been widely used as a surrogate for treatment success. A...

journal_title：American heart journal

authors： Wong CK,de la Barra SL,Herbison P

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:It has been reported that mineralocorticoid receptor antagonist improves the prognosis of chronic heart failure (CHF). Recently, hemoglobin A₁(c) (HbA₁(c)) levels have been reported to be an independent risk factor for mortality in CHF, suggesting the important role of insulin resistance in CHF. We compared ...

journal_title：American heart journal

authors： Yamaji M,Tsutamoto T,Kawahara C,Nishiyama K,Yamamoto T,Fujii M,Horie M

更新日期：2010-11-01 00:00:00

abstract：AIMS:There is a growing concern about the occurrence of coronary artery aneurysms (CAAs) after drug-eluting stent (DES) implantation and their long-term course. We assessed the occurrence and the factors affecting the long-term outcome of DES-associated CAA. METHODS AND RESULTS:We analyzed 3,612 consecutive patients (...

journal_title：American heart journal

authors： Ahn CM,Hong BK,Kim JY,Min PK,Yoon YW,Lee BK,Kwon HM,Kim JS,Ko YG,Choi D,Hong MK,Jang Y,Shim WH,Cho SY,Kim BK,Oh S,Jeon DW,Yang JY,Jung JH

更新日期：2010-11-01 00:00:00

abstract：:Adverse drug events affect millions of patients each year. An important drug-drug interaction between amiodarone and vitamin K antagonists is encountered frequently in daily clinical practice. Warfarin, a commonly used anticoagulant, is a mixture of 2 optically active isomers (R and S enantiomers). The S enantiomer is...

journal_title：American heart journal

authors： Shirolkar SC,Fiuzat M,Becker RC

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Acute pericarditis is common, yet uncertainty persists on its treatment. We thus aimed to conduct a comprehensive systematic review on pharmacologic treatments for acute or recurrent pericarditis. METHODS:Controlled clinical studies were searched in several databases and were included provided they focused ...

journal_title：American heart journal

authors： Lotrionte M,Biondi-Zoccai G,Imazio M,Castagno D,Moretti C,Abbate A,Agostoni P,Brucato AL,Di Pasquale P,Raatikka M,Sangiorgi G,Laudito A,Sheiban I,Gaita F

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the leading cause of death among blacks and whites in the United States. Despite this, there are insufficient data on the long-term prognosis of black patients with coronary artery disease (CAD) as well as the major clinical related determinants of outcome. METHODS:We studied 22,61...

journal_title：American heart journal

authors： Thomas KL,Honeycutt E,Shaw LK,Peterson ED

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Quality improvement programs have shown increased use of beta-blockers post-myocardial infarction (MI), but there are no data on whether appropriate doses are administered. METHODS:In a prospective registry that enrolled consecutive patients with MI, we evaluated beta-blocker dosing at discharge after MI an...

journal_title：American heart journal

authors： Goldberger JJ,Bonow RO,Cuffe M,Dyer A,Rosenberg Y,O'Rourke R,Shah PK,Smith SC Jr,PACE-MI Investigators.

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The prodrug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding enzymes for clopidogrel activation are polymorphic, leading to reduced or increased function, depending on the respective genotype. Reduced-function alleles have been associated with ...

journal_title：American heart journal

authors： Tiroch KA,Sibbing D,Koch W,Roosen-Runge T,Mehilli J,Schömig A,Kastrati A

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Few telemedicine programs have undergone cost analyses, impeding their implementation into practice. We report on the economic analysis of a nurse-administered intervention designed to improve blood pressure control among hypertensive veterans. METHODS:We randomized hypertensive patients at the Durham Veter...

journal_title：American heart journal

authors： Datta SK,Oddone EZ,Olsen MK,Orr M,McCant F,Gentry P,Bosworth HB

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Preoperative use of angiotensin-blocking drug therapy (ABDT) with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and its link to occurrence of postoperative atrial fibrillation (POAF), a common marker of poor outcomes after cardiac surgery, remain controversial. METHODS:From 19...

journal_title：American heart journal

authors： Rader F,Van Wagoner DR,Gillinov AM,Blackstone EH

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Patients with atrial fibrillation (AF) are at increased risk for ischemic stroke. In patients who have suffered a stroke, screening for AF is routinely performed only for a short period after the stroke as part of the evaluation for possible causes. If AF is detected after an ischemic stroke, oral anticoagul...

journal_title：American heart journal

authors： Sinha AM,Diener HC,Morillo CA,Sanna T,Bernstein RA,Di Lazzaro V,Passman R,Beckers F,Brachmann J

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:The LaFarge equation is the most commonly used equation to estimate oxygen consumption (Vo(2)) in patients of all ages with congenital heart disease, although it was generated in patients older than 3 years. We sought to determine the validity of the LaFarge equation in estimating Vo(2) in children younger t...

journal_title：American heart journal

authors： Rutledge J,Bush A,Shekerdemian L,Schulze-Neick I,Penny D,Cai S,Li J

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Chronic total occlusion (CTO) recanalizations remain extremely challenging procedures. With improvements in technology and techniques, success rates for recanalization of CTO continue to improve. However, the clinical benefits of this practice remain unclear. The aim of the study was to determine the effecti...

journal_title：American heart journal

authors： Joyal D,Afilalo J,Rinfret S

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Compared with men, women have more evidence of myocardial ischemia with no obstructive coronary artery disease. Although low endogenous estrogen levels are associated with endothelial dysfunction, the role of low-dose hormone therapy has not been fully evaluated. We postulate that a 12-week duration of low-d...

journal_title：American heart journal

authors： Merz CN,Olson MB,McClure C,Yang YC,Symons J,Sopko G,Kelsey SF,Handberg E,Johnson BD,Cooper-DeHoff RM,Sharaf B,Rogers WJ,Pepine CJ

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Coronary artery disease (CAD) is the most common cause of left ventricular systolic dysfunction (LVSD). Patients with ischemia as the cause of LVSD may warrant revascularization. Angiography is the most accurate method of CAD diagnosis but is invasive, expensive, and associated with some risk. Noninvasive im...

journal_title：American heart journal

authors： Reynolds HR,Steckman DA,Tunick PA,Kronzon I,Lobach I,Rosenzweig BP

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:During daytime working hours, outcomes may be worse when percutaneous coronary intervention (PCI) is performed later in the day because of operator fatigue and differences in process of care. METHODS:Using the APPROACH database, we analyzed 2,492 consecutive nonurgent PCI procedures performed during working...

journal_title：American heart journal

authors： Cantor WJ,Strauss BH,Graham MM,Southern DA,Woo K,Tyrrell B,Knudtson M,Ghali WA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Red cell transfusions are lifesaving in severely anemic or acutely bleeding patients but may be associated with an increased risk of cardiovascular events in critically ill patients. The objective of the study was to examine the association between duration of pretransfusion storage of red cells and in-hospi...

journal_title：American heart journal

authors： Eikelboom JW,Cook RJ,Liu Y,Heddle NM

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Recent data indicate that cardiac antibodies play an active role in the pathogenesis of dilated cardiomyopathy (DCM) and may contribute to cardiac dysfunction in patients with DCM. The present study investigated the influence of immunoadsorption with subsequent immunoglobulin G substitution (IA/IgG) on cardi...

journal_title：American heart journal

authors： Herda LR,Trimpert C,Nauke U,Landsberger M,Hummel A,Beug D,Kieback A,Dörr M,Empen K,Knebel F,Ewert R,Angelow A,Hoffmann W,Felix SB,Staudt A

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:No-reflow after primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) is associated with poor prognosis. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor that might aggravate reperfusion injury. The aim of our study was to assess the relationship be...

journal_title：American heart journal

authors： Eitel I,Nowak M,Stehl C,Adams V,Fuernau G,Hildebrand L,Desch S,Schuler G,Thiele H

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Weekly fish consumption has been related to a lower risk of fatal coronary heart disease (CHD) and incident stroke in populations with a low fish intake. This relation has mainly been attributed to n-3 fatty acids in fish, that is, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). It is at present ...

journal_title：American heart journal

authors： Geleijnse JM,Giltay EJ,Schouten EG,de Goede J,Oude Griep LM,Teitsma-Jansen AM,Katan MB,Kromhout D,Alpha Omega Trial Group.

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Elevated resting heart rate (RHR) is known to be associated with reduced survival but inconsistencies remain, including lack of significance in most studies of healthy women, lack of independence from systolic blood pressure (SBP) in some, and the suggestion that RHR is merely functioning as a marker of phys...

journal_title：American heart journal

authors： Cooney MT,Vartiainen E,Laatikainen T,Juolevi A,Dudina A,Graham IM

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Whether low-molecular-weight heparin (LMWH) is superior to unfractionated heparin (UFH) in acute ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) remains unclear. METHODS:A total of 3,372 STEMI patients wh...

journal_title：American heart journal

authors： Li YJ,Rha SW,Chen KY,Poddar KL,Jin Z,Minami Y,Wang L,Dang Q,Li GP,Ramasamy S,Park JY,Choi CU,Kim JW,Kim EJ,Park CG,Seo HS,Oh DJ,Jeong MH,Ahn YK,Hong TJ,Park JS,Kim YJ,Hur SH,Seong IW,Chae JK,Cho MC,Bae

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The timely and accurate identification of symptoms of acute coronary syndrome (ACS) is a challenge for patients and clinicians. It is unknown whether response times and clinical outcomes differ with specific symptoms. We sought to identify which ACS symptoms are related-symptom clusters-and to determine if s...

journal_title：American heart journal

authors： Riegel B,Hanlon AL,McKinley S,Moser DK,Meischke H,Doering LV,Davidson P,Pelter MM,Dracup K

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Relationships between long-term use and level of dual antiplatelet therapy and outcomes after drug-eluting stent implantation are not well established. METHODS:This is a retrospective cohort study of 9,256 patients receiving drug-eluting stents between January 2003 and August 2006. We classified patients ac...

journal_title：American heart journal

authors： Petersen JL,Barron JJ,Hammill BG,Cziraky MJ,Anstrom KJ,Wahl PM,Eisenstein EL,Krucoff MW,Califf RM,Schulman KA,Curtis LH

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Conflicting data exist regarding a potential deleterious association between aspirin (ASA) and angiotensin-converting enzyme inhibitors (ACEIs) when used concurrently in patients with heart failure (HF). How such an interaction may be influenced by underlying etiology of HF and whether it extends to patients...

journal_title：American heart journal

authors： Levy PD,Nandyal D,Welch RD,Sun JL,Pieper K,Ghali JK,Fonarow GC,Gheorghiade M,O'Connor CM

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Preoperative evaluation with contrast-enhanced multidetector computed tomographic angiography (MDCTA) is considered an "appropriate" indication based on expert consensus. We aimed to evaluate how the presurgical evaluation with MDCTA impacts the outcomes after reoperative cardiac surgery (RCS). METHODS:We r...

journal_title：American heart journal

authors： Maluenda G,Goldstein MA,Lemesle G,Weissman G,Weigold G,Landsman MJ,Hill PC,Pita F,Corso PJ,Boyce SW,Pichard AD,Waksman R,Taylor AJ

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Studies document better survival in heart failure patients with decreased left ventricular ejection fraction (EF) and higher body mass index (BMI; kg/m(2)) compared to those with a lower BMI. However, it is unknown if this "obesity paradox" applies to heart failure patients with preserved EF or if it extends...

journal_title：American heart journal

authors： Kapoor JR,Heidenreich PA

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Despite advances in treatment of cardiogenic shock (CS), the incidence of this serious complication of acute ST-elevation myocardial infarction (STEMI) has stayed relatively constant, and rates of mortality, although somewhat improved in recent decades, remain dauntingly high. Although both percutaneous coro...

journal_title：American heart journal

authors： Mehta RH,Lopes RD,Ballotta A,Frigiola A,Sketch MH Jr,Bossone E,Bates ER

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Erythropoietin mitigates myocardial damage and improves ventricular performance after experimental ischemic injury. This study assessed safety and efficacy markers relevant to the biological activity of recombinant human erythropoietin (rHuEpo) in patients with acute myocardial infarction (MI). METHODS:We c...

journal_title：American heart journal

authors： Tang YD,Hasan F,Giordano FJ,Pfau S,Rinder HM,Katz SD

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:The study aimed to determine the impact on eptifibatide-associated bleeding by implementing a computerized dosing algorithm in the cardiac catheterization suite. BACKGROUND:Excessive dosing of eptifibatide is associated with increased bleeding rates and hospital mortality. Although dosing adjustments based o...

journal_title：American heart journal

authors： Putney DR,Kleiman NS,Fromm RE Jr,Buergler JM

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:High-intensity interval training has been shown to be superior to moderate continuous exercise training in improving exercise capacity and endothelial function in patients with coronary artery disease. The objective of this study was to evaluate this training model on in-stent restenosis following percutaneo...

journal_title：American heart journal

authors： Munk PS,Staal EM,Butt N,Isaksen K,Larsen AI

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Current practice related to the management of atrial fibrillation (AF) complicating coronary artery bypass grafting (CABG) is uncertain. METHODS:We examined management of post-CABG AF in the PREVENT-IV trial, and we explored patterns of use of postoperative rhythm versus rate control and anticoagulation for...

journal_title：American heart journal

authors： Al-Khatib SM,Hafley G,Harrington RA,Mack MJ,Ferguson TB,Peterson ED,Califf RM,Kouchoukos NT,Alexander JH

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Symptoms of anxiety are associated with increased risk of coronary artery disease and potentially poor prognosis among patients with existing coronary artery disease, but whether symptoms of anxiety influence atherosclerotic progression among such patients is uncertain. Accordingly, we evaluated the hypothes...

journal_title：American heart journal

authors： Rosenbloom JI,Wellenius GA,Mukamal KJ,Mittleman MA

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:More than three fourths of patients with heart failure (HF) are 65 years and older, and older age is associated with worse symptoms and prognoses than is younger age. Reduced exercise capacity is a chief HF complaint and indicates poorer prognosis, especially among elderly persons, but the mechanisms underly...

journal_title：American heart journal

authors： Forman DE,Clare R,Kitzman DW,Ellis SJ,Fleg JL,Chiara T,Fletcher G,Kraus WE,HF-ACTION Investigators.

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:In the treatment of coronary artery disease, a "pro-healing" approach for prevention of in-stent restenosis and late stent thrombosis is intuitively favored over the use of cytotoxic or cytostatic drugs released from a drug-eluting stent (DES). Promoting accelerated endothelial coverage of the stent surface,...

journal_title：American heart journal

authors： Klomp M,Beijk MA,Verouden NJ,Tijssen JG,de Winter RJ,TRIAS Investigators.

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Limited data are available on the care of patients with acute severe hypertension requiring hospitalization. We characterized contemporary practice patterns and outcomes for this population. METHODS:STAT is a 25-institution, US registry of consecutive patients with acute severe hypertension (>180 mm Hg syst...

journal_title：American heart journal

authors： Katz JN,Gore JM,Amin A,Anderson FA,Dasta JF,Ferguson JJ,Kleinschmidt K,Mayer SA,Multz AS,Peacock WF,Peterson E,Pollack C,Sung GY,Shorr A,Varon J,Wyman A,Emery LA,Granger CB,STAT Investigators.

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:The significance of troponin elevation and clinical utility of troponin testing in ambulatory patients with coronary artery disease (CAD) have not been examined. We sought to investigate the prevalence and prognostic value of cardiac troponin T (cTnT) elevation in a population with stable CAD. METHODS:We st...

journal_title：American heart journal

authors： Hsieh BP,Rogers AM,Na B,Wu AH,Schiller NB,Whooley MA

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:beta-blockers have been shown to benefit patients after myocardial infarction by decreasing mortality, sudden cardiac death, and reinfarction. Although beta-blockers are recommended for all patients with acute coronary syndromes (ACS) without contraindications, a target heart rate (HR) is recommended only fo...

journal_title：American heart journal

authors： Herman M,Donovan J,Tran M,McKenna B,Gore JM,Goldberg RJ,Tighe DA

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Although hospital admissions during weekends have been associated with worse quality of care and worse outcomes in some but not all medical conditions, the impact of weekend versus weekday admission and discharge for heart failure (HF) has not been well studied. This study investigates the association of (1)...

journal_title：American heart journal

authors： Horwich TB,Hernandez AF,Liang L,Albert NM,Labresh KA,Yancy CW,Fonarow GC,Get With Guidelines Steering Committee and Hospitals.

更新日期：2009-09-01 00:00:00